Our concept “Sequence Data Management” (SDM) doesn’t fit the primary/secondary/tertiary analysis informatics categories. Why? Because we’ve coupled the alignment step with the analysis step in one-shot. Why is that better? Biologists can to compute the data on their own and mine the data in an easy to use web application. They are able to “finish the pipeline on their own”. Hopefully, this will to more interesting biological conclusions and more enthusiastic end-users of NGS technology.